Microbatch screening finds more
leads
than VD in a given time
J. Crystal Growth. 168 (1996), pp 170-174.
or: http://www.douglas.co.uk/rep2.htm |
Microbatch
produces
MB crystals of firefly luciferase. Data could not be collected
from VD crystals which were unstable. Courtesy of E. Conti. Acta Crystallographica.
D 52 (1996), 4, pp 876-878
http://www.douglas.co.uk/rep3.htm |
large diffracting
crystals
MB crystal of alcohol dehydrogenase from a thermophilic bacterium.
Courtesy of Y. Korkhin. Acta Crystallographica. D 52 (1996), pp 882-886.
http://www.douglas.co.uk/rep1.htm |
Software for multivariate
experiments
including Central Composite (shown) and Box-Behnken designs
.
J. Crystal Growth 196 (1999) 665-73 or ...
douglas.co.uk/rat_des.htm |
High productivity
the method uses fewer personnel and has a lower capital cost
|
Method |
Plates dispensed per day |
Wells per protein |
Proteins screened per day |
|
Manual vapor diffusion |
10 (24 wells) |
192 |
1.25 |
|
Automated regular V.D |
16 (24 wells) |
192 |
2 |
|
Automated microbatch |
12 (96 wells) |
192 |
4.5 |
http://www.douglas.co.uk/proposal.htm#resources |
